This anti-ageing protein may increase longevity and combat obesity, cancer

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Scientists have revealed the three-dimensional (3D) structure of an anti-ageing protein, that may not only increase human lifespan but also help develop therapies for age-related diseases such as diabetes, obesity and cancers. The Klotho proteins — alpha and beta — named after the Greek goddess Clotho, who spun the thread of life, play an important role in the regulation of longevity and metabolism.

Both work in tandem with molecules called endocrine FGFs, which regulate metabolic processes in tissues and organs including the brain, liver and kidneys, among other organs. In the study, led by researchers from Yale University, the team found that beta-Klotho is the primary receptor that binds to FGF21 — a key hormone produced upon starvation.

FGF21 has the potential for boosting insulin sensitivity and glucose metabolism, causing weight loss. This new understanding of beta-Klotho and FGF21 can guide the development of therapies for conditions such as Type 2 diabetes in obese patients, the researchers said, in a paper published in the journal Nature.

Source: hindustantimes